Liver Cancer News
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Circadian Clock Contributes To Poor Prognosis Of Hepatocellular Carcinoma Patients
29 March 2017
New research has suggested that disruption of the circadian clock contributes to poor prognosis of Hepatocellular Carcinoma (HCC) patients. Suprachiasmatic nucleus in the hypothalamus is the seat of the central circadian clock and synchronizes peripheral clocks through the body. At the molecular level, this entails a negative feedback loop between the CLOCK-BMAL1 heterodimer and its transcriptional targets period and cryptochrome. The 24-hour cycle driven by these factors coordinates metabolic gene expression with the feeding and fasting/day and night cycle. Some studies have recently suggested that disruption of the circadian rhythm is associated with tumor initiation and progression.
MicroRNAs Regulate Energy Metabolism In Hepatocellular Carcinoma Cells
28 March 2017
The role of microRNAs (miRNA) in the regulation of the Warburg effect in Hepatocellular Carcinoma (HCC) has been established. Cancer cells rewire their metabolism to promote growth, survival, proliferation, and long-term maintenance. The common feature of this altered metabolism is the increased glucose uptake and fermentation of glucose to lactate. This phenomenon is observed even in the presence of completely functioning mitochondria and, together, is known as the Warburg Effect. However, the underlying mechanisms of the Warburg effect remain largely unknown.
Winning The Battle V. Cancer
28 March 2017
Prof. Xu Kecheng, a renowned specialist in gastroenterology, hepatology, and cancer treatment, and founder of the Fuda Cancer Hospital, was diagnosed with a rare and often fatal liver cancer 11 years ago. From being the brave doctor, helping others fight their bruising battles against cancer, he is now the patient, facing the Big C himself. After undergoing surgery, he was surfing the Internet when he came across an article by a doctor from Taiwan who reviewed 81 patients who got hepatectomy, of whom only 11 survived more than five years. He read that these patients who had cholangiocarcinoma (like him) could receive “adjutant chemotherapy with medium survival time one to three months longer than the control group without chemo.”
Surveillance In High-Risk Patients With NAFLD Key To Preventing, Delaying HCC
27 March 2017
Increasing rates of obesity and type 2 diabetes in patients has been associated with a high risk for Hepatocellular Carcinoma following the development of non-alcoholic fatty liver disease, according to a presenter at Emerging Trends in Non-Alcoholic Fatty Liver Disease.
ArQule (ARQL) Says Phase 3 Clinical Study of Tivantinib In Hepatocellular Carcinoma In Japan Didn’t Meet Primary Endpoint
27 March 2017
ArQule, Inc. (Nasdaq: ARQL) today reported that its partner, Kyowa Hakko Kirin, announced top-line results of the JET-HCC Phase 3 trial of tivantinib in Japan, and that the trial did not meet its primary endpoint of progression free survival (PFS).
Detecting Mutations Could Lead To Earlier Liver Cancer Diagnosis
27 March 2017
In many parts of the world, including Southeast Asia and sub-Saharan Africa, exposure to a fungal product called aflatoxin is believed to cause up to 80 percent of liver cancer cases. This fungus is often found in corn, peanuts, and other crops that are dietary staples in those regions.
MIT researchers have now developed a way to determine, by sequencing DNA of liver cells, whether those cells have been exposed to aflatoxin. This profile of mutations could be used to predict whether someone has a high risk of developing liver cancer, potentially many years before tumors actually appear.
World’s First AI That Can Diagnose Cancer From A Blood Sample ‘Could Be Ready In One Year’
24 March 2017
A machine that can detect cancer from a blood sample could be ready in a year. Scientists in California have developed a computer program that can detect tumor DNA as well as specify where in the body it is coming from. The program, dubbed CancerLocator, works by looking for specific molecular patterns in cancer DNA. Created by a team from the University of California at Los Angeles, it then compares these patterns against a database of genetic modifications known to be caused by different cancer types.
Report Shows Increase In Liver Cancer Among Iowans
22 March 2017
A new report from the State Health Registry of Iowa shows the rate of new liver cancer cases has tripled in the state since the 1970s. According to the “Cancer in Iowa” report released Wednesday, new cases of liver cancer were detected in six of 100,000 Iowans in the period from 2010 to 2014.
Dr. Michael Voigt is a clinical professor of internal medicine at University of Iowa Hospitals and Clinics. He said hepatitis B and hepatitis C are the primary risk factors for liver cancer.
Overweight Teenagers at Heightened Risk of Liver Disease
22 March 2017
Being overweight as a teenager may increase the risk for liver illness later in life, a new study has found. Swedish researchers used data on more than 1.2 million young men ages 17 to 19 who were drafted into the military from 1969 to 1996, then linked the data to government health records. At conscription, 104,137 were overweight; with a body mass index between 25 and 29, and 19,671 were obese (B.M.I. over 30). The study, published in Gut, found 5,281 cases of severe liver disease and 251 cases of liver cancer over a median follow-up of 29 years.
Microbial Signature for Liver Cancer: Gastro Endo News Report
22 March 2017
People with Hepatocellular Carcinoma may have a microbial signature that ups their cancer risk, a new study found. Colorectal cancer rates are on the rise in young adults between 20 and 39 years old, but on decline in the over-50 crowd, according to recent data. Fecal calprotectin appears to be indicative of gastrointestinal bleeding, which researchers discovered by having patients drink their own blood.
Obesity in Youth Tied to Liver Cancer Risk in Men
21 March 2017
Overweight and obese young men are at increased risk for serious liver disease or liver cancer later in life, and those with diabetes have an even higher risk, a new study warns. Efforts to reduce obesity, “should be implemented from an early age to reduce the future burden of severe liver disease on individuals and society,” say Swedish researchers led by Hannes Hagstrom, of the Center for Digestive Diseases at Karolinska University Hospital in Stockholm.
Man With Liver Cancer Alleges Negligence For Failure To Follow Up On Lab Work
20 March 2017
A patient is suing Family and Sports Medicine Shiloh and a doctor for allegedly failing to perform follow-up lab work, leaving his liver cancer undiagnosed. Mickey Orr filed a complaint on Feb. 3 in the St. Clair County Circuit Court against Richard Derby, M.D., and HSHS Medical Group, doing business as Family and Sports Medicine Shiloh, alleging they failed to properly diagnose the plaintiff with liver cancer. According to the complaint, Orr alleges that in May 2015, he began treatment with Derby, an employee of HSHS Medical Group. Orr’s lab work necessitated further tests, including tests for liver cancer. However, he claims the defendant did not obtain those results, leaving his liver cancer undiagnosed at the time.
Risks Following RFA For Liver Cancer In ESRD Patients On Hemodialysis Investigated
20 March 2017
For patients with end-stage renal disease (ESRD), receipt of hemodialysis (HD) is associated with increased mortality after radiofrequency ablation (RFA) for Hepatocellular Carcinoma, according to a study published online March 7 in the Journal of Gastroenterology and Hepatology. Masaya Sato, from the University of Tokyo, and colleagues used a nationwide database to examine in-hospital mortality and hemorrhagic complications following RFA among patients on HD for ESRD. For each patient enrolled, up to four non-dialyzed patients were randomly selected. The authors compared in-hospital mortality and hemorrhagic complications between dialyzed and non-dialyzed patients (437 and 1,345 patients, respectively) following RFA.
Doctors A Step Closer To Give Liver Cancer Patients More Healing Opportunities
17 March 2017
Researchers from the National Cancer Centre Singapore (NCCS) and the A*STAR’s Genome Institute of Singapore (GIS) supported by the National Medical Research Council (NMRC) Translational and Clinical Research (TCR) flagship program Precision Medicine in Liver Cancer across Asia-Pacific Network (PLANET) have made a discovery that could transform the treatment of Hepatocellular Carcinoma (HCC), the most common but deadly type of liver cancer. The discovery revealed that the genetic characteristics of liver cancer tumors can vary widely, not only across different patients but also within a single tumor. This hinted that healing the patient needs a precision medicine, which is a treatment customized to the needs of each patient.
S’pore Team’s Work Set To Change How Liver Cancer Is Treated
17 March 2017
The leader of a team of Singapore researchers doing groundbreaking work into liver cancer turned to the tale of the blind men who touched an elephant to point out that previous studies had wrongly assumed the nature of the cancer from just one point of view, that is, one biopsy. The team, from the National Cancer Centre Singapore (NCCS) and the Agency for Science, Technology and Research’s Genome Institute of Singapore (GIS), found that the genetic characteristics of liver cancer tumors can vary widely, not only across different patients but also across different parts of a single tumor from one patient.
‘Backwards Step’ Reveals Cancer Cells Are ‘Smart Little Bastards’
16 March 2017
Targeting the ‘Achilles’ heel’ of liver cancer could have unintended consequences, encouraging rather than preventing tumor growth, UNSW researchers warn. Liver cancer is the third leading cause of cancer-related death worldwide and is the fastest growing cancer in Australia. “Many people suspect an Achilles’ heel of liver cancer is a metabolic process in cells called lipogenesis, which converts sugars into fats,” says Associate Professor Kyle Hoehn from UNSW. “This fat production is thought to play an important role in helping cancer cells proliferate.”
Hepatocellular Carcinoma in the USA
15 March 2017
The incidence and mortality of Hepatocellular Carcinoma have been reported to be plateauing in the United States. The United States has large racial, ethnic, and regional variation. Dr. Hashem El-Serag and colleagues from Texas, USA collected data from all 50 states to better analyze changes in Hepatocellular Carcinoma incidence in the entire United States. The researchers collected data from the US Cancer Statistics registry, which covers 97% of the population, and calculated adjusted incidence rates.
New Smilow Liver Cancer Program Aims To Maximize Value Of Care For Patients
15 March 2017
In the last 10 years, there has been a constant growth in the number of patient with primary liver cancer treated at Yale New Haven Hospital and at Smilow Cancer Hospital. Smilow is one of the few medical centers able to offer to patients with primary liver cancer a comprehensive array of therapeutic approaches and personalized care, according to the needs of each patient. These considerations have justified the formation of a freestanding Liver Cancer Program.
MRI-Guided Ultrasound Blasts Liver Cancer
14 March 2017
The EU-funded TRANS-FUSIMO project, being led by the Fraunhofer Institute for Medical Image Computing MEVIS in Bremen, is developing a technique in which high intensity focused ultrasound is used to target specific areas of the liver. High intensity focused ultrasound uses sound waves to target a precise location in the body, generating a hot spot that can destroy diseased tissue. Until now, however, the method has only been approved for use in treating a limited number of conditions, such as prostate cancer, bone metastases, and uterine fibroids.
TwoXAR Announces Preclinical Proof-of-Concept Data On Novel Liver Cancer Candidate
14 March 2017
An artificial intelligence (AI)-driven biopharmaceutical company, today announced that its candidate targeting Hepatocellular Carcinoma (HCC or Liver Cancer), TXR-311, has shown positive results in cell-based assays. TXR-311 is a molecule that twoXAR identified as having a high probability of being effective in treating HCC. Proof-of-concept studies were performed by The Asian Liver Center at Stanford University. The objective of these studies was to establish preliminary cytotoxicity data in cell-based assays for 10 separate candidates.
Occlusion Of The Portal Liver Vein To Permit Liver Surgeries For Liver Cancer
13 March 2017
Hepatocellular Carcinoma (HCC) is the most common type of liver cancer. This type of cancer starts in the liver (primary liver cancer). When other cancers spread to the liver, it is known as secondary liver cancer. When possible, surgery is the main treatment because it still is the best options for treating primary and secondary liver cancer. As the liver is able to re-grow itself, surgeons are able to remove affected sections of the liver completely (liver resection). However, a certain amount of the liver must remain in order for the liver to re-grow. Patients who require a large section of their liver to be removed can undergo a portal vein embolization (PVE) which tries to get the liver to grow prior to a liver resection. A needle is placed through the skin into the liver and the blood vessel that has the largest amount of the tumor is embolized (cut off) by injecting an embolizing material (that is similar to glue). This tricks the liver into regrowing on the side without the tumor.
Treatment Of Intermediate-Stage Primary Liver Cancer (Hepatocellular Carcinoma)
10 March 2017
Hepatocellular Carcinoma (primary liver cancer) arises from the liver cells and is distinct from secondary liver cancer, arising from other parts of the body and spreading to the liver. Hepatocellular Carcinoma can be classified in many ways. One classification is by Barcelona Clinic Liver Cancer (BCLC) group stage, which classifies the cancer based on how long the person is expected to live (life expectancy). This classification is broadly based on the size of the cancer, number of cancers in the liver, how well the liver works, and whether one’s activities are affected by the cancer. People with intermediate-stage Hepatocellular Carcinoma have large, multiple cancers, but they do not have full-blown liver failure. Cancer is confined to the liver, and there is no restriction of daily activities. There is significant uncertainty in the treatment of people with intermediate-stage Hepatocellular Carcinoma.
Can Antiviral Therapy Prevent Liver Cancer in Patients With Chronic Hepatitis?
10 March 2017
Chronic viral hepatitis is a major causative factor for Hepatocellular Carcinoma, but antiviral therapy might reduce the incidence of Hepatocellular Carcinoma by preventing or eliminating chronic hepatitis infections, according to Adrian M. Di Bisceglie, MD, Professor of Internal Medicine at Saint Louis University Liver Center in St. Louis, Missouri.
Liver Cancer Rates With Interferon-Free Regimens in HIV/HCV
8 March 2017
The risk of developing liver cancer continues to be high in patients co-infected with HIV/hepatitis C virus (HCV). However, a new study presented at CROI 2017 is suggesting that the incidence of Hepatocellular Carcinoma after sustained virological response (SVR) has not increased with the widespread use of all oral direct antivirals regimens as suggested in previous studies.
Low-Cost FDM 3D Printing Can Help In Fight Against Liver Cancer
8 March 2017
The impact of 3D technology developments on healthcare in recent years has been undeniable, and a recent breakthrough by researchers in Poland suggests that the medical profession is poised to benefit even further from what 3D printing has to offer. A 3D printed model of a liver was produced, at a much lower cost than previously thought possible, and the model was used successfully as a surgical guide for a crucial operation to remove a potentially fatal tumor.
Clinical Data Shows Surefire Technology Achieved 79% Objective Response Versus 37% Using a Standard Microcatheter In Treating Primary Liver Cancer
8 March 2017
Surefire Medical, Inc. today announced that clinical data presented at the Society for Interventional Radiology (SIR) Annual Scientific Meeting in Washington, DC showed in a retrospective case-controlled comparison that the use of Surefire infusion technology achieved a 79 percent objective response rate in the treatment of primary liver cancer (Hepatocellular Carcinoma or HCC) in transarterial chemoembolization procedures (TACE) versus 37 percent with a standard microcatheter.
Radiotherapy Administered Externally For Advanced Hepatocellular Carcinoma
7 March 2017
Hepatocellular Carcinoma (primary liver cancer) is the most common cancerous tumor of the liver and the sixth most common cancerous tumor worldwide. In the majority of people with Hepatocellular Carcinoma, the disease is diagnosed at the advanced stage. Treatment options for these people include ablation (which destroys the tumor), embolization (the use of substances to block or decrease the flow of blood through the hepatic artery to the tumor), radiotherapy, or sorafenib, which is a targeted drug therapy (a treatment that uses a substance to identify and attack cancer cells while avoiding normal cells).
Exelixis (EXEL) Reports Orphan Drug Designation For Cabozantinib To Treat Hepatocellular Carcinoma
6 March 2017
Exelixis, Inc. (Nasdaq: EXEL) today announced that the U.S. Food & Drug Administration (FDA) has granted orphan drug designation to cabozantinib for the treatment of Hepatocellular Carcinoma (HCC). This information was posted to FDA’s website on March 4, 2017 and can be accessed here. A pivotal phase 3 trial (CELESTIAL) of cabozantinib is ongoing in patients with advanced HCC, and Exelixis has guided that data from the trial are expected in 2017.
How New Hepatitis C Drugs Could Tackle Liver Cancer, Too
6 March 2017
Wider availability of newer hepatitis C drugs may not only lead to fewer cases of this blood-borne disease, but may also slow the rise in related liver cancer. But these so-called direct acting antiviral drugs have not been widely available in Australia or overseas for long enough for us to confirm this long-term trend.
Cabozantinib Active In Hepatocellular Carcinoma
6 March 2017
Treatment with cabozantinib was clinically active and associated with manageable toxicities in patients with advanced, recurrent, or metastatic Hepatocellular Carcinoma (HCC), according to a study published in Annals of Oncology. For the multicohort, phase 2 trial (ClinicalTrials.gov Identifier: NCT00940225), investigators enrolled adult patients with 9 different types of advanced malignancies, including 41 patients with HCC. All patients with HCC had Child-Pugh A liver function and had received no more than 1 prior systemic regimen.
Researchers Have “New Attitude” About Liver Cancer
3 March 2017
While the liver cancer landscape is not as explosive with novel agents as some other solid tumor types, systemic and surgical advancements are still having an impact on the lives of patients. In January 2017, a supplemental biologics license application for the multikinase inhibitor regorafenib (Stivarga) was granted priority review by the FDA as a second-line treatment for patients with unresectable Hepatocellular Carcinoma (HCC).
Test Identifies And Isolates Circulating Tumor Cells; Aids Early Detection of Liver Cancer
3 March 2017
Identifying a single cancer cell in a sample of whole blood is akin to finding a needle in the proverbial haystack. However, a team from the Massachusetts General Hospital Cancer Center has developed a method that improves the detection of circulating tumor cells (CTCs) ¾ the “needle” ¾ in the blood of patients with Hepatocellular Carcinoma (HCC), the most common type of liver cancer. Their report was published in the journal PNAS. The team employed droplet digital PCR (ddPCR), an advanced variation of the commonly used polymerase chain reaction (PCR) method, to find CTCs to try to improve the early diagnosis of liver cancer. PCR measures the quantity of RNA (a nucleic acid that naturally occurs in the cells); ddPCR is like having tens of thousands of tiny test tubes (the droplets) each running an individual PCR. This technique allows for more accurate quantification of these RNAs, which are then used as surrogate markers for the presence of liver cancer.
Dumaguing: The Journey To Liver Cancer
3 March 2017
There are many causes of liver cancer and we would like our readers to be informed with our hope and fervent prayer that awareness of this would raise our antennae of suspicion when it shows its presence. After all, an ounce of prevention is worth more than a pound of cure. Or as many of us elders know, forewarned is forearmed.
New Liver Cancer Treatment Combines Chemotherapy And Immunotherapy To Prevent Tumor Growth, Extend Survival
2 March 2017
Hepatocellular Carcinoma, the most common form of liver cancer, has low long-term survival rates, and the current drugs approved to treat it only extend lifespan by about three months. While researchers at the University of Missouri School of Medicine emphasize that any preservation of life is worthwhile, they are on the heels of something even greater, and claim their newly developed liver tumor treatment could extend patient survival rates much farther. According to a recently published study, this new treatment involves the use of both chemotherapy and immunotherapy, and in animal studies has significantly slowed the acceleration of liver tumor growth in mice. This slow-down of tumor growth was more significant than that produced by either the standard chemotherapy or immunotherapy when used on their own.
Dr. Roberts On The Prevalence Of Liver Cancer
1 March 2017
Lewis R. Roberts, MB, ChB, PhD, professor of Medicine, Mayo Clinic, discusses the prevalence of Hepatocellular Carcinoma (HCC). It is important to remember that of all of the major cancer types worldwide, liver cancer remains to be one of the most fatal, Roberts explains. Most patients are more likely to die within 1 year of being diagnosed compared with patients who have other types of cancers.
New Findings On Liver Cancer From First Affiliated Hospital Summarized
28 February 2017
New Findings on Liver Cancer from First Affiliated Hospital Summarized (Metavir and FIB-4 scores are associated with patient prognosis after curative hepatectomy in hepatitis B virus-related Hepatocellular Carcinoma: a retrospective cohort …) By a News Reporter-Staff News Editor at China Weekly News Research findings on Oncology – Liver Cancer are discussed in a new report. According to news reporting originating in Chongqing, People’s Republic of China, by VerticalNews journalists, research stated, “Although Metavir and Fibrosis-4 (FIB-4) scores are typically used to assess the severity of liver fibrosis, the relationship between these scores and patient outcome in Hepatocellular Carcinoma (HCC) is unclear. The aim of this study was to evaluate the prognostic value of the severity of hepatic fibrosis in HBV-related HCC patients after curative resection.”
Exelixis Links With BMS To Test Potential Cancer Combo
28 February 2017
Exelixis and Bristol-Myers Squibb Company have formed a clinical development collaboration to evaluate a potential new combination therapy for the treatment of various cancers. The groups will assess a combination of Exelixis’ Cabometyx (cabozantinib), a small molecule inhibitor of receptor tyrosine kinases, and BMS’ PD-1 immune checkpoint inhibitor Opdivo (nivolumab), either alone or in combination with Yervoy (ipilimumab), as a first line treatment for renal cell carcinoma.
Pediatric Hepatocellular Carcinoma: Challenges and Solutions
23 February 2017
Unlike in adults, Hepatocellular Carcinoma (HCC) is a very rare malignancy in children, representing only approximately 0.5% to 1% of all pediatric tumors. Because fewer than 20% of pediatric patients with HCC are considered eligible for surgical resection, which is considered fundamental for cure, the management of HCC remains difficult in this population.
Personalized Treatment For Very Early Stage Hepatocellular Carcinoma
23 February 2017
A proposed algorithm to facilitate the decision-making process of clinical care for patients with very early stage Hepatocellular Carcinoma (HCC) provides optimal personalized treatment strategies for these patients, according to a review published in the Journal of Hepatology.
NeuroVive Enters Research Agreements In NASH And Hepatocellular Carcinoma
23 February 2017
NeuroVive Pharmaceutical AB, the mitochondrial medicine company, announced two new research agreements and the appointment of Professor Philippe Gallay, PhD, and Professor Massimo Pinzani, MD, PhD, FRCP, as scientific advisors. The aim of the agreements is to further explore NeuroVive’s new drug compounds in development for the treatment of NASH and Hepatocellular Carcinoma (HCC).
Genetic Variant Linked To Risk of Liver Cancer After Hep C Eradication
22 February 2017
A single nucleotide polymorphism (SNP) in the tolloid-like 1 (TLL1) gene is associated with the development of hepatocellular carcinoma (HCC) after eradication of hepatitis C virus (HCV) infection, researchers from Japan report. “When we constructed different models for predicting HCC in patients with mild as opposed to advanced hepatic fibrosis by combining this TLL1 variant with other distinct risk factors, these proposed models including TLL1 variant could be useful for predicting the occurrence of HCC after achieving sustained virological response (SVR) in the clinical practice,” Dr. Yasuhito Tanaka from Nagoya City University Graduate School of Medical Sciences told Reuters Health by email.
New Tech Will Improve Liver Cancer Recovery
21 February 2017
New technology to provide detailed scans of patients could improve the recovery of people suffering with liver cancer, scientists have said. According to researchers, the new LiverMultiScan will provide advanced imagery and can help doctors have a clearer picture of the organ, tumors or inflammation before carrying out surgery. HepaT1ca — an NHS Foundation project by the University of Edinburgh and Hampshire Hospitals — created the technology, which act as detailed MRI scans and cost £1.1 million to develop.
Welling To Lead New Liver Cancer Program At NYU Langone
20 February 2017
NYU Langone has announced Theodore H. Welling III, MD, will lead a new state-of-the-art liver cancer program at the medical center to advance clinical care and accelerate the translation of lab breakthroughs into superior treatments. Previously co-director of the Multidisciplinary Liver Tumor Program at the University of Michigan Health System, Welling joins NYU Langone’s Perlmutter Cancer Center to lead a team that has already made important strides in refining clinical practices to treat primary liver cancer and hepatic metastases, according to a release from NYU Langone. He will help to recruit additional investigators and clinicians to the program.
Ivan “The Russian Bear” Koloff, Professional Wrestler, Dies At 74 From Liver Cancer
18 February 2017
The bearded grappler became a notorious villain, and fan favorite, in the wrestling world during the 1970s and 1980s. Ivan Koloff, who rose to fame as the villainous “Russian Bear” in the WWWF during the 1970s and 1980s, has died of liver cancer, according to a statement from World Wrestling Entertainment. He was 74. Though Koloff’s wrestling persona reigned from the Ukraine, the wrestler was actually born and raised in Canada.
Phase 3 Hepatocellular Carcinoma Trial Fails
17 February 2017
A Phase 3 study of Daiichi Sankyo and ArQule’s tivantinib (ARQ 197), a designed treatment for MET-overexpressing Hepatocellular Carcinoma (HCC) did not meet its primary endpoint of improving overall survival in patients.
Study Provides Insight Into How MicroRNA May Amplify Effects Of Drug Treatment In Liver Cancer
17 February 2017
Treatment options for liver cancer are often limited and almost exclusively involve transplantation if possible, or local chemoembolization and radiofrequency ablation. Medical treatments for more advanced stages have been explored during recent decades, but only the drug sorafenib, a small molecule multi-kinase inhibitor, has shown promising results and been approved for use by international medical agencies. Unfortunately, only 25% of patients respond to sorafenib treatment, so researchers have endeavored to understand its mechanism of action and discover a way to boost its effectiveness.
Virus Passed Through Sex Could Cause Cirrhosis Or ‘Silent Killer’ Cancer
17 February 2017
Liver cancer and cirrhosis are just two of the risks with can arise from contracting hepatitis B – a virus which can be spread through unprotected sex. Hepatitis B is an infection of the liver, caused by a virus spread through blood and bodily fluids. Public Health England has published new flyers and posters warning people of the dangers of hepatitis B. The poster reads, “Hepatitis B virus infects the liver; it is often symptomless but can lead to diseases like cirrhosis and liver cancer.
Daiichi, ArQule’s Struggling Tivantinib Fails In Phase 3 Liver Cancer Test
17 February 2017
After fluffing its lines in two mid-to-late stage trials in lung and colorectal cancer over the past few years, Daiichi and ArQule had hoped that tivantinib could produce the goods in a phase 3 liver cancer test, but it was not to be. In data released this morning, the partners said their MET-inhibitor med did not meet its primary endpoint of improving overall survival in Hepatocellular Carcinoma (the most common form of liver cancer) in 340 patients. The trial, dubbed METIV-HCC, was set up as a biomarker-selected, double-blind, placebo-controlled, phase 3 study that looked at tivantinib against best supportive care in patients with MET-overexpressing, inoperable HCC who cannot take, or were previously treated, with systemic therapy.
University Health System Awarded $1.2M To Help Combat Hepatitis C
16 February 2017
The Cancer Prevention and Research Institute of Texas awarded the University Health System with $1.2 million Wednesday to increase screening for hepatitis C and prevent the development of liver cancer. According to UHS, South Texas has the highest incidence of liver cancer in the nation, largely due to hepatitis C. Researchers said they have found that the baby boomer population — born from 1945 to 1965 — had more than twice the rate of hepatitis C in the nation, with Hispanics also at higher risk.
Social Jet Lag Linked To Liver Cancer In Mice
14 February 2017
“Hepatocellular Carcinoma is one of the most lethal liver cancers and the only one for which the number of new cases is increasing in the United States,” says co-senior author Dr. David Moore, professor of molecular and cellular biology and of molecular and human genetics at Baylor College of Medicine. “In many countries outside the U.S. hepatitis B and C virus are driving the increase of Hepatocellular Carcinoma, but in the U.S. this is not the case. Many researchers think Hepatocellular Carcinoma is likely the result of non-alcoholic fatty liver disease and obesity. However, how non-alcoholic fatty liver disease leads to Hepatocellular Carcinoma is still unclear.” Unraveling how disruptions in the internal clock can lead to cancer is quite challenging. In addition to a central timekeeper in the brain, it seems that each type of tissue has its own clock. The connections between the central clock and the rest of the clocks form a complex network of factors that regulate the expression of number of genes. “It’s possible that it is not just the fat accumulated in the liver, but that there is something else. We think that, at least to some degree, bile acids are involved,” Moore said.
World Cancer Day 2017: Liver Cancer, A Global Challenge Thanks To Viruses And Alcohol
13 February 2017
Liver cancer is not that common in the UK. It accounts for around 2 in every 100 newly diagnosed cancers each year and is the 17th most common type of cancer. But since the late 1970s, liver cancer rates have more than tripled in the UK — a sharp rise compared to other types of cancer. Globally, however, liver cancer poses an even bigger challenge. It is the sixth most common cancer worldwide, approaching 800,000 new cases diagnosed each year, mostly in low-to-middle-income countries. The regions hardest hit by liver cancer are parts of Asia and Africa.
Pro Wrestling Pioneer Chavo Guerrero Sr. Dies After Fight With Liver Cancer
11 February 2017
Chavo Guerrero Sr., one of the pro wrestling world’s most respected performers, has died after a short battle with liver cancer. He was 68. Guerrero’s son and namesake, Chavo Guerrero Jr., who also wrestled with WWE, made the announcement on Saturday.
UN: Aflatoxins, The Major Cause Of Liver Cancer In Africa
9 February 2017
A number of liver cancer cases in Africa are linked to aflatoxins, a family of toxins produced by fungi. Heiner Lehr, UN Industrial Development Organisation (UNIDO) national expert on value chain, made this known on Wednesday while delivering a keynote address at the first Nigeria food safety and investment forum in Lagos. He said the presence of aflatoxins, which affects crops on the field, during harvest and storage, pose serious danger to consumers. Aflatoxins are produced by fungi like Aspergillus flavus and Aspergillus parasiticus, which are abundant in warm and humid regions of the world.
Mailed Outreach Program Increases Ultrasound Screening of Patients With Cirrhosis for Hepatocellular Carcinoma
8 February 2017
Outreach strategies increase the percentage of patients with cirrhosis who undergo Hepatocellular Carcinoma (HCC) screening, according to a study published in the February issue of Gastroenterology. Amit G. Singal, MD, from the University of Texas Southwestern Medical Center in Dallas, and colleagues conducted a prospective study of patients with documented or suspected cirrhosis at a safety-net health system.
High Rates of Hepatocellular Carcinoma After Hepatitis C Treatment
8 February 2017
Patients treated with direct-acting antiviral (DAA) therapy for hepatitis C virus (HCV)-related cirrhosis appear to have high rates of Hepatocellular Carcinoma (HCC). “If these findings are confirmed from other centers, studies are suggested to examine mechanisms of these findings,” Dr. Ashwani Singal from University of Alabama at Birmingham told Reuters Health by email. Some studies have shown unexpectedly high HCC recurrence rates after DAA therapy, whereas others have shown no such association.
Partners To Develop Chemotherapeutic Technology As Liver Cancer Treatment
7 February 2017
Q BioMed said today that it will partner with the Oklahoma Medical Research Foundation (OMRF) and the Rajiv Gandhi Centre for Biotechnology (RGCB) to develop a chemotherapeutic technology to treat liver cancer. Q BioMed said the technology will use uttroside B and its derivatives as a chemotherapeutic agent against Hepatocellular Carcinoma. Uttroside B is a saponin derived from Solanum nigrum Linn, a plant widely used in traditional medicine that showed efficacy against liver cancer in a preclinical study published November 3 in Scientific Reports, a Nature journal.
Prominent Surgeon And Researcher To Lead Multidisciplinary Liver Cancer Initiative
6 February 2017
Theodore H. Welling, III, MD, will lead a new state-of-the-art liver cancer program at NYU Langone to advance clinical care and accelerate the translation of lab breakthroughs into superior treatments. Welling joins the medical center’s Perlmutter Cancer Center as director of a new Liver Tumor Program following a distinguished career at the University of Michigan Health System, where he serves as co-director of its Multidisciplinary Liver Tumor Program. His work includes nationally recognized advances in liver transplantation, laparoscopic liver surgery, and surgery requiring expertise in bile duct and hepatic vascular resection and reconstruction. His clinical expertise has been deepened by investigative work into new treatments for cholangiocarcinoma and Hepatocellular Carcinoma. Welling also is studying the role of the immune system and cancer stem cells on liver cancer development and progression. His investigative work has been consistently supported by the National Institutes of Health.
Doctors’ Notes: Why Toronto Is A Liver Cancer Hot Spot
6 February 2017
Liver cancer is to blame for more than a thousand deaths every year in Ontario — and most of these occur in the Greater Toronto Area. In fact, the epidemic level of liver cancer in this city often goes unrecognized, as it is diluted by provincial and national statistics. So what is it about Toronto that makes it such a hot spot for this type of cancer? Most of the cases occur in patients with chronic liver disease, typically due to chronic blood-borne infections with the hepatitis B or C viruses.
Hope In Horizon: Vaccines Can Prevent Liver Cancer
5 February 2017
On World Cancer Day, on Saturday, while many chose to highlight latest innovations and diagnostic techniques to treat the disease, some experts from the city decided to put focus on vaccines that can prevent cancers — Hepatitis B and human papillomavirus (HPV). While Hepatitis B viral infection can cause liver cancer and cirrhosis (abnormal liver condition), HPV is known to cause cervical cancer among women. Both these cancers are, however, preventable through vaccines. Yet, the cancer burden of the two diseases is huge with Hepatitis B infection showing a prevalence rate of more than 3 per cent among people.
Blood Transfusions May Increase Risk For HCC
3 February 2017
Risks for Hepatocellular Carcinoma and non-Hodgkin lymphoma appeared greater among women who had undergone a blood transfusion more than 5 years earlier, according to results of a prospective study conducted in the United Kingdom. A total of 11,274 women underwent transfusion in 2000 or later, of whom 14.6% (n = 1,648) were diagnosed with cancer a mean 6.8 years after the blood transfusion. Women who underwent transfusion were older at baseline and more likely to smoke, drink less alcohol, have increased BMI and have come from the deprived tertile of the population.
Liver Cancer Patients Wanted For New Clinical Trial
3 February 2017
A new way of treating liver cancer, which combines two existing treatments, is now on trial, with researchers from four medical institutions seeking patients to join the study. The treatment strategy being tested, dubbed a world first by the researchers, sees a patient being treated with both radioembolization and immunotherapy. The current treatment for liver cancer patients is Yttrium-90 (Y90) radioembolization, which involves putting radioactive isotopes into blood vessels that feed a tumor, delivering radiation to the tumor. Immunotherapy involves activating the body’s immune system to fight cancer cells. By combining the two, researchers hope to boost outcomes.
Risk Of Liver Cancer Low In Patients With Cirrhosis
1 February 2017
Liver cancer — or Hepatocellular Carcinoma (HCC) — is one of the most serious complications of cirrhosis, or scarring of the liver, caused by long-term liver damage. However, an analysis of health records, published in the academic journal Alimentary Pharmacology and Therapeutics, found that the 10-year incidence of HCC in UK patients with cirrhosis is actually only four per cent, or lower. The study found that only 1.2 per cent of patients with alcoholic cirrhosis and 1.1 per cent of patients with cirrhosis of unknown cause will develop HCC within a decade. The highest 10-year incidence of HCC was among those with cirrhosis due to chronic viral hepatitis (four per cent).
Childhood Liver Cancer Treatment
Fortunately, cancer in children and adolescents is rare, although the overall incidence of childhood cancer has been slowly increasing since 1975. Children and adolescents with cancer should be referred to medical centers that have a multidisciplinary team of cancer specialists with experience treating the cancers that occur during childhood and adolescence. This multidisciplinary team approach incorporates the skills of the primary care physician, pediatric surgical subspecialists, radiation therapists, pediatric oncologists/hematologists, rehabilitation specialists, pediatric nurse specialists, social workers, and others to ensure that children receive treatment, supportive care, and rehabilitation that will achieve optimal survival and quality of life.
Early Detection Of Liver Cancer Saves Lives
30 January 2017
Liver Cancer is the second leading cause of cancer-related death globally, accounting for approximately 746,000 deaths worldwide a year2. In Europe, less than 10 percent of patients live for more than five years after diagnosis. In this framework, Bayer’s Pharmaceuticals division calls for early detection of liver cancer to help saves lives, highlighting that the disease afflicts around 4 percent of cancer patients in Lebanon, and is projected to rise to over 6 percent of cases among women and around 8 percent of cases among men by 2018. “Liver cancer causes death more often than many other tumors, and patients are usually diagnosed with late-stage disease,” said Dr. Fady Nasr, Head of the Oncology Department at Beirut’s Mount Lebanon Hospital.
Oregon Liver Cancer Deaths Soaring
28 January 2017
Liver cancer deaths in Oregon are growing at twice the national rate, likely due to a high prevalence of hepatitis C infections. Oregon once boasted a liver cancer death rate 33 percent lower than the U.S. average. But over the past 35 years, liver cancer deaths in Oregon have risen so fast, the state has almost entirely closed the gap. According to data released Tuesday by the Institute for Health Metrics and Evaluation at the University of Washington, 6.81 out of every 100,000 Americans died of liver cancer in 2014, an increase of 88 percent since 1980. In Oregon, the death rate was 6.74 percent, representing a 174 percent increase.
Sirtex Medical to Present Liver Cancer Study Results in the Netherlands
27 January 2017
Sirtex’s SARAH study is a Phase III multi-center prospective randomized open-label study for patients in France with advanced Hepatocellular Carcinoma (HCC). HCC is the most common form of primary liver cancer, a cancer that starts in the liver. The SARAH study will be presented at the International Liver Congress on Saturday, 22 April 2017. The SARAH study directly compares Sirtex’s SIR-Spheres® Y-90 resin microspheres versus the current standard-of-care systemic therapy, sorafenib.
Frontline Lenvima Is Noninferior to Standard Therapy in Liver Cancer Trial
26 January 2017
Frontline Lenvima (lenvatinib) was not inferior to the current standard therapy, Nexavar (sorafenib), in patients with unresectable Hepatocellular Carcinoma (HCC), according to Eisai, the developer of the multikinase inhibitor.
Seymour High School Student Looking for Liver Transplant After Cancer Diagnosis
26 January 2017
Jarrid Rynish, an 18-year-old senior at Seymour High School, was diagnosed with liver cancer in 2016. Now, the community is supporting this young man with a big heart, as he is in search of a liver donation.
Phase III Trial of Anticancer Agent Lenvima as First-Line Treatment for Unresectable Hepatocellular Carcinoma Meets Primary Endpoint
25 January 2017
Eisai Co., Ltd. announced today that a Phase III clinical trial (Study 304) of its in-house discovered and developed anticancer agent Lenvima (lenvatinib mesylate, “lenvatinib”) against the comparator sorafenib as a first-line treatment for patients with unresectable Hepatocellular Carcinoma has achieved its primary endpoint.
4SC AG: Overall Survival Benefit for Resminostat in First-Line Liver Cancer Study Subgroup
25 January 2017
4SC AG (4SC, FSE Prime Standard: VSC) today announced that the study investigators presented the detailed scientific study analysis from the multi-center, randomized, 170 patient Phase II study conducted by 4SC’s cooperation partner Yakult Honsha Co., Ltd. (Yakult Honsha) in Japan and South Korea at the 2017 Gastrointestinal Cancers Symposium in San Francisco, USA. The study evaluated 4SC’s epigenetic cancer drug resminostat in combination with sorafenib compared to sorafenib monotherapy as first-line treatment in patients with advanced liver cancer.
Eisai’s Lenvima Moves Toward Nexavar Showdown With Phase 3 Liver Cancer Win
25 January 2017
Right now, Bayer has the only FDA-approved first-line treatment for Hepatocellular Carcinoma (HCC), by far the most common type of liver cancer. But thanks to some new trial results for Eisai, it may not be alone for long. On Wednesday, the Japanese pharma announced that its Lenvima had hit the primary endpoint in a phase 3 study, establishing noninferiority against Bayer’s Nexavar on the overall survival front. The med also charted statistically significant improvements in progression-free survival, among other secondary endpoints. The move brings Eisai one step closer to challenging Bayer in a hefty market: An estimated 27,000-plus U.S. patients died of liver cancer in 2016, Eisai said, and an estimated 39,000 new cases will be diagnosed stateside this year.
Bristol Looks To Exploit Opdivo’s Liver Cancer Advantage
23 January 2017
Bristol-Myers Squibb might have seen its PD-1 inhibitor Opdivo comprehensively outmaneuvered by Merck & Co.’s Keytruda in lung cancer, but the opposite could be the case in Hepatocellular Carcinoma. Updated data from the dose-expansion stage of Bristol’s large Checkmate-040 Phase I/II study reported at ASCO-GI suggest that the drug confers a durable response in around 20% of hepatocellular patients – irrespective of whether it is given first or second line (see tables below). With a near-term Phase III study readout Bristol looks to have first-mover advantage over its arch-rival.
SBRT Equivalent to TACE as Bridge to Transplant for Patients With HCC
22 January 2017
Use of stereotactic body radiation therapy (SBRT) was equally effective as transarterial chemoembolization (TACE) as a method of bridge to transplant among patients with Hepatocellular Carcinoma, according to preliminary results of a phase II study presented recently at the 2017 American Society of Clinical Oncology (ASCO) Gastrointestinal Cancers Symposium, held January 19 – 21 in San Francisco. “SBRT appears equivalent to TACE at controlling the treated lesion when utilized as a bridge to transplant in patients with Childs-Pugh class A/B disease,” said study presenter Francis W. Nugent, MD, of Lahey Hospital and Medical Center, Burlington, Mass.
Progression Type in HCC Influences Survival Duration
21 January 2017
Patients with advanced Hepatocellular Carcinoma (HCC) had a worse survival following progression if they developed new extrahepatic lesions as opposed to other types of progression, supporting the concept of post-progression survival (PPS) and the influence of different patterns of progression, according to an analysis of the phase III RESORCE trial.
Regorafenib Improves Overall Survival in Liver Cancer
20 January 2017
Second-line systemic therapy with regorafenib improves overall survival among patients with Hepatocellular Carcinoma (HCC) regardless of prior sorafenib dose, according to a study being presented at the 2017 Gastrointestinal Cancers Symposium.
NeuroVive Presents Positive Preclinical Data in Hepatocellular Cancer at HCC Summit
19 January 2017
NeuroVive has utilized its expertise in mitochondrial medicine to explore a unique aspect of the company’s sanglifehrin-based compounds. In preclinical studies, the NeuroVive research team and its international collaborators have shown that a sub-set of these compounds exert unexpectedly potent anticancer effects. An abstract with the title Preclinical analysis of sanglifehrin-based cyclophilin inhibitors showing potential for treatment of Hepatocellular Carcinoma will be presented at the conference.
Mount Sinai Researchers Involved in Successful Phase 3 Trial of Drug for Liver Cancer
18 January 2017
An international phase 3 trial has found that the drug regorafenib improved survival in patients with advanced Hepatocellular Carcinoma (HCC), a form of liver cancer, giving people who previously had no other options a better chance at survival. Results from the study, which included researchers at The Tisch Cancer Institute at the Icahn School of Medicine at Mount Sinai, were recently published online in The Lancet. The trial, funded by Bayer, included 152 sites in 21 countries.
Stop Eating Contaminated Maize And Groundnuts To Avoid Liver Cancer
18 January 2017
Scientists are warning against high-level consumption of contaminated maize and groundnuts, saying, that could lead to liver cancer (Hepatocellular Carcinoma). People who ate such foods they indicated tended to have more aflatoxins in their blood and stood a higher risk of developing the cancer.
10 Things You Might Not Know About Your Liver From Mount Alvernia Doctor
18 January 2017
Dr. Ala said liver cancer is currently the ninth most common cause of cancer death in the UK and since the late 1970s, liver cancer incidence rates have more than tripled (236% increase) in Great Britain. Dr. Ala, consultant gastroenterologist endoscopist and hepatologist has shed light on 10 lesser known, essential facts about the liver and its functions.
Link Between Sweetener and Liver Cancer Probed
18 January 2017
A James Cook University researcher will use a grant from the Cancer Council to investigate the relationship between fructose – a common sweetener in soft drinks – and liver cancer, an increasingly prevalent and deadly cancer.
How to Prevent the Killer That is Liver Cancer
17 January 2017
This is not a rare, esoteric health problem. Liver cancer ranks number two among all killer cancers. It is the fourth most common type of cancer, right up there together with breast and lung cancer,” says Dr. Eternity Labio, immediate past president of the Hepatology Society of the Philippines. A leading cause of liver cancer as well as liver cirrhosis is hepatitis B, an infectious disease caused by the hepatitis B virus (HBV). Eighty percent of infections are found in Asia. As of the latest estimates, about one in seven adult Filipinos carries the virus. “It’s more common than you think,” Dr. Labio says. “However, you can have it and not know it. It often does not manifest any signs or symptoms until the liver damage is already extensive. Patients come in when they already have cirrhosis or liver cancer.”
National Obesity Awareness Week 2017: Sleep Problems, Cirrhosis, Liver Cancer
14 January 2017
National Obesity Awareness Week runs from January 9 through January 15, 2017 and to wrap it up we present some of our articles that discuss obesity and related health issues, such as sleep problems, cirrhosis, and liver cancer. Additional evidence has become known linking obesity to liver cancer. The study found that a larger waistline, high body mass index, and type 2 diabetes increase a person’s risk for liver cancer.
‘Little Brother’ in Pursuit of His Dreams Dies of Liver Cancer
11 January 2017
A Cincinnati teenager who cleared many hurdles while fighting an aggressive cancer has died.
Figures Reveal Major Rise in Liver Cancer Cases
9 January 2017
New figures show a dramatic rise in the number of cases of liver cancer diagnosed in Ireland. The national Cancer Registry of Ireland says the annual rate stood at around 60 in the mid-1990s. In 2014, that rose to more than 270. The incidence rate of the disease has increased significantly since 1994 for males and females with annual average increases of 5% for women and of 6.5% for men.
CoQ10 Supplementation Shows Benefits for Liver Cancer Patients Post-Surgery
9 January 2017
A 300mg daily coenzyme Q10 supplement significantly increased antioxidant capacity and reduced oxidative stress and inflammation levels post-surgery for patients with Hepatocellular Carcinoma (HCC) – the most common type of liver cancer.
Researchers Testing New Cancer Treatment
8 January 2017
Liver cancer is the sixth most common cancer in the world, and now researchers are developing new forms of treatment. If tests show you have liver cancer, there are several ways to treat the disease. One is removing the cancerous part of the liver. The other is having doctors replace the organ through a transplant operation. Now scientists are working on an experimental, minimally invasive treatment. They say it reduces the chances of harming the patient. Kattesh Katti is a professor of radiology and physics at the University of Missouri’s School of Medicine. For more than 10 years, he has studied the use of nanotechnology to fight cancer. “It sounds like a fairy tale, but we are really in advanced stages in terms of tumor treatment, in terms of disease diagnostics.”
Amzie Smith, Louisville teen who inspired thousands with message of faith, dies at 17 from liver cancer
7 January 2017
Amzie Smith, the Ballard High School junior who inspired thousands with her message of faith during her battle with terminal cancer, died on Friday afternoon. The 17-year-old was diagnosed with stage 4 adult liver cancer in November 2015 – a kind of cancer rarely found in adults and nearly unheard of in children. According to an online post from Tad Douglas, Amzie’s stepfather, Amzie “passed away peacefully” Friday afternoon holding hands with her family members, “as she went to be with the Lord.”
Sorafenib Effect on HCC Survival Depends on Hepatitis Status
6 January 2017
For patients with advanced unresectable Hepatocellular Carcinoma, the effect of sorafenib on overall survival is dependent on patients’ hepatitis status, according to a meta-analysis published online Jan. 3 in the Journal of Clinical Oncology.
Effect of Sorafenib on OS Dependent on Viral Status
5 January 2017
The effect of sorafenib on overall survival may depend on the hepatitis status of patients with advanced hepatocellular carcinoma (HCC), according to a study published in the Journal of Clinical Oncology. Findings from the Sorafenib Hepatocellular Carcinoma Assessment Randomized Protocol (SHARP) trial led to sorafenib becoming the standard of care for patients with advanced unresectable HCC.
Dramatic Drop in Cancer Deaths, but One Cancer Still Up
5 January 2017
The death rate from all cancers combined in the United States has dropped by 25% over the past 2.5 decades, although cancer incidence and mortality rates are typically higher in men and racial disparities still exist, a Cancer Statistics 2017 report indicates. However, liver cancer continues to increase in the United States, as has been reported previously by Medscape Medical News.
Non-Liver-Related Critical Events Down With SVR in HCV+Cirrhosis
4 January 2017
For patients with hepatitis C virus (HCV) infection and biopsy-proven cirrhosis, sustained viral response (SVR) is associated with a reduction in critical events, both liver and non-liver related, according to research published in the January issue of Gastroenterology.
FDA Grants Bayer Priority Review for Stivarga® (regorafenib) for the Second-Line Systemic Treatment of Liver Cancer
4 January 2017
Bayer today announced that the U.S. Food and Drug Administration (FDA) has granted priority review status for the supplemental New Drug Application (sNDA) for Stivarga® (regorafenib) tablets for the second-line systemic treatment of patients with Hepatocellular Carcinoma (HCC) in the U.S. HCC is the most common form of liver cancer, a disease that affects nearly 40,000 patients in the United States and is the second deadliest form of cancer worldwide.
Non-alcoholic fatty liver disease on the rise
3 January 2017
Last month, news of Deputy Speaker of Parliament Charles Chong undergoing a liver transplant took many people by surprise. Three years ago, the MP for Punggol East, 63, was diagnosed with a severe form of non-alcoholic fatty liver disease (NAFLD) steatohepatitis but did not make it public. While NAFLD is an unfamiliar term to most people, a recently released study by SingHealth doctors found that its incidence is rising in Singapore, and could well be affecting half of the adults here.
Inspyr Therapeutics Initiates Mipsagargin with Nexavar® Combination Therapy Programs for Liver Cancer
3 January 2017
Inspyr Therapeutics, a clinical-stage biotechnology company developing a novel prodrug therapeutic for the treatment of cancer, announced the initiation of development programs focused on Mipsagargin combination therapies. To evaluate the potential of Mipsagargin in combination with Nexavar®, Inspyr plans to conduct a preclinical study in liver PDX tumor models that express PSMA, the target of Mipsagargin. The tumor models selected express different levels of PSMA, including one that is resistant to Nexavar®. Concurrently, the Company is finalizing the design of a clinical study to examine the potential benefits of Mipsagargin in combination with Nexavar® in patients with advanced Hepatocellular Carcinoma (HCC), or liver cancer.
For past liver cancer news, please visit our Liver Cancer News Archives.