(Also called primary liver cancer, hepatoma, and HCC.) Hepatocellular carcinoma is the most common primary malignant liver tumor in which the cancer starts in cells of the liver. Hepatocellular carcinoma is also the fourth most common cancer in the world. Symptoms include: abdominal pain, unexplained weight loss, unexplained fevers, abdominal swelling, appearance of ascites, muscular wasting, bloating, decreased appetite, and nausea. Jaundice and swelling of the legs occur in more advanced liver cancer. Many patients with hepatocellular carcinoma do not develop symptoms until the advanced stages of the tumor. Hepatitis B and C appear to be the most significant causes of hepatocellular carcinoma worldwide.