Alkylating agent A family of cytotoxic drugs that depurinate DNA, which prevents normal cell division. Alkylating agents kill cells when they are either resting or dividing. The reagent replaces a specific group in a molecule with an alkyl group. Leave a Reply Cancel reply Your email address will not be published. Required fields are marked *Comment Name * Email * Website Save my name, email, and website in this browser for the next time I comment.